diff --git a/test/e2e/storage/testsuites/ephemeral.go b/test/e2e/storage/testsuites/ephemeral.go
index f9e7a69113e..89166bd3b62 100644
--- a/test/e2e/storage/testsuites/ephemeral.go
+++ b/test/e2e/storage/testsuites/ephemeral.go
@@ -109,6 +109,7 @@ func (p *ephemeralTestSuite) DefineTests(driver storageframework.TestDriver, pat
 		resource *storageframework.VolumeResource
 	}
 	var (
+		dInfo   = driver.GetDriverInfo()
 		eDriver storageframework.EphemeralTestDriver
 		l       local
 	)
@@ -132,6 +133,11 @@ func (p *ephemeralTestSuite) DefineTests(driver storageframework.TestDriver, pat
 				e2eskipper.Skipf("Cluster doesn't support %q volumes -- skipping", pattern.VolType)
 			}
 		}
+		// A driver might support the Topology capability which is incompatible with the VolumeBindingMode immediate because
+		// volumes might be provisioned immediately in a different zone to where the workload is located.
+		if pattern.BindingMode == storagev1.VolumeBindingImmediate && len(dInfo.TopologyKeys) > 0 {
+			e2eskipper.Skipf("VolumeBindingMode immediate is not compatible with a multi-topology environment.")
+		}
 
 		l = local{}