diff --git a/test/e2e/node/node_problem_detector.go b/test/e2e/node/node_problem_detector.go
index b4d2434c098..23101674bd0 100644
--- a/test/e2e/node/node_problem_detector.go
+++ b/test/e2e/node/node_problem_detector.go
@@ -35,7 +35,7 @@ import (
 
 // This test checks if node-problem-detector (NPD) runs fine without error on
 // the nodes in the cluster. NPD's functionality is tested in e2e_node tests.
-var _ = SIGDescribe("NodeProblemDetector", func() {
+var _ = SIGDescribe("NodeProblemDetector [DisabledForLargeClusters]", func() {
 	const (
 		pollInterval = 1 * time.Second
 		pollTimeout  = 1 * time.Minute