diff --git a/build/root/Makefile b/build/root/Makefile
index af5239b3f7d..f463cd96f99 100644
--- a/build/root/Makefile
+++ b/build/root/Makefile
@@ -221,7 +221,9 @@ define TEST_E2E_NODE_HELP_INFO
 # Args:
 #  FOCUS: Regexp that matches the tests to be run.  Defaults to "".
 #  SKIP: Regexp that matches the tests that needs to be skipped.
-#    Defaults to "\[Flaky\]|\[Slow\]|\[Serial\]".
+#    Defaults to "\[Flaky\]|\[Slow\]|\[Serial\]" unless LABEL_FILTER is set.
+#    If LABEL_FILTER is set, then no tests are skipped by default.
+#  LABEL_FILTER: Use Ginkgo labels query language to filter the tests to be run. May contain spaces and special characters (exclamation mark, vertical bar, etc.) but not quotation marks.
 #  TEST_ARGS: A space-separated list of arguments to pass to node e2e test.
 #    Defaults to "".
 #  RUN_UNTIL_FAILURE: If true, pass --until-it-fails=true to ginkgo so tests are run
diff --git a/hack/make-rules/test-e2e-node.sh b/hack/make-rules/test-e2e-node.sh
index 1c5ca5d5459..0ef5480c4da 100755
--- a/hack/make-rules/test-e2e-node.sh
+++ b/hack/make-rules/test-e2e-node.sh
@@ -29,7 +29,12 @@ KUBE_PANIC_WATCH_DECODE_ERROR="${KUBE_PANIC_WATCH_DECODE_ERROR:-true}"
 export KUBE_PANIC_WATCH_DECODE_ERROR
 
 focus=${FOCUS:-""}
-skip=${SKIP-"\[Flaky\]|\[Slow\]|\[Serial\]"}
+label_filter=${LABEL_FILTER:-""}
+if [ -n "${label_filter}" ]; then
+  skip=${SKIP:-""} # No default skip when LABEL_FILTER is set.
+else
+  skip=${SKIP-"\[Flaky\]|\[Slow\]|\[Serial\]"}
+fi
 # The number of tests that can run in parallel depends on what tests
 # are running and on the size of the node. Too many, and tests will
 # fail due to resource contention. 8 is a reasonable default for a
@@ -79,6 +84,10 @@ if [[ ${skip} != "" ]]; then
   ginkgoflags="${ginkgoflags} -skip=\"${skip}\" "
 fi
 
+if [[ ${label_filter} != "" ]]; then
+  ginkgoflags="${ginkgoflags} --label-filter=\"${label_filter}\" "
+fi
+
 if [[ ${run_until_failure} == "true" ]]; then
   ginkgoflags="${ginkgoflags} --until-it-fails=true "
 fi