diff --git a/test/e2e/common/network/networking.go b/test/e2e/common/network/networking.go
index 3f8d463399a..452707edc78 100644
--- a/test/e2e/common/network/networking.go
+++ b/test/e2e/common/network/networking.go
@@ -131,14 +131,12 @@ var _ = SIGDescribe("Networking", func() {
 			}
 		})
 
-		// [Disruptive] because it conflicts with tests that call CheckSCTPModuleLoadedOnNodes
-		ginkgo.It("should function for intra-pod communication: sctp [LinuxOnly][Feature:SCTPConnectivity][Disruptive]", func(ctx context.Context) {
+		ginkgo.It("should function for intra-pod communication: sctp [LinuxOnly][Feature:SCTPConnectivity]", func(ctx context.Context) {
 			config := e2enetwork.NewNetworkingTestConfig(f, e2enetwork.EnableSCTP)
 			checkPodToPodConnectivity(config, "sctp", e2enetwork.EndpointSCTPPort)
 		})
 
-		// [Disruptive] because it conflicts with tests that call CheckSCTPModuleLoadedOnNodes
-		ginkgo.It("should function for node-pod communication: sctp [LinuxOnly][Feature:SCTPConnectivity][Disruptive]", func(ctx context.Context) {
+		ginkgo.It("should function for node-pod communication: sctp [LinuxOnly][Feature:SCTPConnectivity]", func(ctx context.Context) {
 			ginkgo.Skip("Skipping SCTP node to pod test until DialFromNode supports SCTP #96482")
 			config := e2enetwork.NewNetworkingTestConfig(f, e2enetwork.EnableSCTP)
 			for _, endpointPod := range config.EndpointPods {
diff --git a/test/e2e/network/dual_stack.go b/test/e2e/network/dual_stack.go
index b1ae6c0739c..5d473549396 100644
--- a/test/e2e/network/dual_stack.go
+++ b/test/e2e/network/dual_stack.go
@@ -462,8 +462,7 @@ var _ = common.SIGDescribe("[Feature:IPv6DualStack]", func() {
 			}
 		})
 
-		// [Disruptive] because it conflicts with tests that call CheckSCTPModuleLoadedOnNodes
-		ginkgo.It("should function for pod-Service: sctp [Feature:SCTPConnectivity][Disruptive]", func(ctx context.Context) {
+		ginkgo.It("should function for pod-Service: sctp [Feature:SCTPConnectivity]", func(ctx context.Context) {
 			config := e2enetwork.NewNetworkingTestConfig(f, e2enetwork.EnableDualStack, e2enetwork.EnableSCTP)
 			ginkgo.By(fmt.Sprintf("dialing(sctp) %v --> %v:%v (config.clusterIP)", config.TestContainerPod.Name, config.SecondaryClusterIP, e2enetwork.ClusterSCTPPort))
 			err := config.DialFromTestContainer("sctp", config.SecondaryClusterIP, e2enetwork.ClusterSCTPPort, config.MaxTries, 0, config.EndpointHostnames())
diff --git a/test/e2e/network/netpol/network_legacy.go b/test/e2e/network/netpol/network_legacy.go
index 4875c88476a..6702afb60ab 100644
--- a/test/e2e/network/netpol/network_legacy.go
+++ b/test/e2e/network/netpol/network_legacy.go
@@ -1686,7 +1686,10 @@ var _ = common.SIGDescribe("NetworkPolicyLegacy [LinuxOnly]", func() {
 			})
 			cleanupServerPodAndService(f, podA, serviceA)
 		})
-		ginkgo.It("should not allow access by TCP when a policy specifies only SCTP [Feature:NetworkPolicy]", func(ctx context.Context) {
+
+		// This is [Serial] because it can't run at the same time as the
+		// [Feature:SCTPConnectivity] tests, since they may cause sctp.ko to be loaded.
+		ginkgo.It("should not allow access by TCP when a policy specifies only SCTP [Feature:NetworkPolicy] [Serial]", func(ctx context.Context) {
 			ginkgo.By("getting the state of the sctp module on nodes")
 			nodes, err := e2enode.GetReadySchedulableNodes(f.ClientSet)
 			framework.ExpectNoError(err)
@@ -1729,7 +1732,7 @@ var _ = common.SIGDescribe("NetworkPolicyLegacy [LinuxOnly]", func() {
 	})
 })
 
-var _ = common.SIGDescribe("NetworkPolicy [Feature:SCTPConnectivity][LinuxOnly][Disruptive]", func() {
+var _ = common.SIGDescribe("NetworkPolicy [Feature:SCTPConnectivity][LinuxOnly]", func() {
 	var service *v1.Service
 	var podServer *v1.Pod
 	var podServerLabelSelector string
diff --git a/test/e2e/network/netpol/network_policy.go b/test/e2e/network/netpol/network_policy.go
index 05bb2f19113..4cb45cf02bf 100644
--- a/test/e2e/network/netpol/network_policy.go
+++ b/test/e2e/network/netpol/network_policy.go
@@ -1312,7 +1312,7 @@ var _ = common.SIGDescribe("Netpol [LinuxOnly]", func() {
 	})
 })
 
-var _ = common.SIGDescribe("Netpol [Feature:SCTPConnectivity][LinuxOnly][Disruptive]", func() {
+var _ = common.SIGDescribe("Netpol [Feature:SCTPConnectivity][LinuxOnly]", func() {
 	f := framework.NewDefaultFramework("sctp-network-policy")
 	f.SkipNamespaceCreation = true
 	f.NamespacePodSecurityEnforceLevel = admissionapi.LevelBaseline
diff --git a/test/e2e/network/networking.go b/test/e2e/network/networking.go
index 619adfff266..fac8c030fb7 100644
--- a/test/e2e/network/networking.go
+++ b/test/e2e/network/networking.go
@@ -176,8 +176,7 @@ var _ = common.SIGDescribe("Networking", func() {
 			}
 		})
 
-		// [Disruptive] because it conflicts with tests that call CheckSCTPModuleLoadedOnNodes
-		ginkgo.It("should function for pod-Service: sctp [Feature:SCTPConnectivity][Disruptive]", func(ctx context.Context) {
+		ginkgo.It("should function for pod-Service: sctp [Feature:SCTPConnectivity]", func(ctx context.Context) {
 			config := e2enetwork.NewNetworkingTestConfig(f, e2enetwork.EnableSCTP)
 			ginkgo.By(fmt.Sprintf("dialing(sctp) %v --> %v:%v (config.clusterIP)", config.TestContainerPod.Name, config.ClusterIP, e2enetwork.ClusterSCTPPort))
 			err := config.DialFromTestContainer("sctp", config.ClusterIP, e2enetwork.ClusterSCTPPort, config.MaxTries, 0, config.EndpointHostnames())
@@ -219,8 +218,7 @@ var _ = common.SIGDescribe("Networking", func() {
 			}
 		})
 
-		// [Disruptive] because it conflicts with tests that call CheckSCTPModuleLoadedOnNodes
-		ginkgo.It("should function for node-Service: sctp [Feature:SCTPConnectivity][Disruptive]", func(ctx context.Context) {
+		ginkgo.It("should function for node-Service: sctp [Feature:SCTPConnectivity]", func(ctx context.Context) {
 			ginkgo.Skip("Skipping SCTP node to service test until DialFromNode supports SCTP #96482")
 			config := e2enetwork.NewNetworkingTestConfig(f, e2enetwork.EnableSCTP)
 			ginkgo.By(fmt.Sprintf("dialing(sctp) %v (node) --> %v:%v (config.clusterIP)", config.NodeIP, config.ClusterIP, e2enetwork.ClusterSCTPPort))
@@ -264,8 +262,7 @@ var _ = common.SIGDescribe("Networking", func() {
 			}
 		})
 
-		// [Disruptive] because it conflicts with tests that call CheckSCTPModuleLoadedOnNodes
-		ginkgo.It("should function for endpoint-Service: sctp [Feature:SCTPConnectivity][Disruptive]", func(ctx context.Context) {
+		ginkgo.It("should function for endpoint-Service: sctp [Feature:SCTPConnectivity]", func(ctx context.Context) {
 			config := e2enetwork.NewNetworkingTestConfig(f, e2enetwork.EnableSCTP)
 			ginkgo.By(fmt.Sprintf("dialing(sctp) %v (endpoint) --> %v:%v (config.clusterIP)", config.EndpointPods[0].Name, config.ClusterIP, e2enetwork.ClusterSCTPPort))
 			err := config.DialFromEndpointContainer("sctp", config.ClusterIP, e2enetwork.ClusterSCTPPort, config.MaxTries, 0, config.EndpointHostnames())
@@ -635,7 +632,9 @@ var _ = common.SIGDescribe("Networking", func() {
 		framework.ExpectNoError(err, "kubelet did not recreate its iptables rules")
 	})
 
-	ginkgo.It("should allow creating a Pod with an SCTP HostPort [LinuxOnly]", func(ctx context.Context) {
+	// This is [Serial] because it can't run at the same time as the
+	// [Feature:SCTPConnectivity] tests, since they may cause sctp.ko to be loaded.
+	ginkgo.It("should allow creating a Pod with an SCTP HostPort [LinuxOnly] [Serial]", func(ctx context.Context) {
 		node, err := e2enode.GetRandomReadySchedulableNode(f.ClientSet)
 		framework.ExpectNoError(err)
 		hostExec := utils.NewHostExec(f)
diff --git a/test/e2e/network/service.go b/test/e2e/network/service.go
index a797bb0f610..fcaf4eebb71 100644
--- a/test/e2e/network/service.go
+++ b/test/e2e/network/service.go
@@ -3780,7 +3780,9 @@ var _ = common.SIGDescribe("Services", func() {
 		e2epod.DeletePodOrFail(cs, ns, podname1)
 	})
 
-	ginkgo.It("should allow creating a basic SCTP service with pod and endpoints [LinuxOnly]", func(ctx context.Context) {
+	// These is [Serial] because it can't run at the same time as the
+	// [Feature:SCTPConnectivity] tests, since they may cause sctp.ko to be loaded.
+	ginkgo.It("should allow creating a basic SCTP service with pod and endpoints [LinuxOnly] [Serial]", func(ctx context.Context) {
 		serviceName := "sctp-endpoint-test"
 		ns := f.Namespace.Name
 		jig := e2eservice.NewTestJig(cs, ns, serviceName)