diff --git a/test/e2e/framework/google_compute.go b/test/e2e/framework/google_compute.go
index 1738a55bdd3..cf937b72f5b 100644
--- a/test/e2e/framework/google_compute.go
+++ b/test/e2e/framework/google_compute.go
@@ -35,8 +35,12 @@ func lookupClusterImageSources() (string, string, error) {
 	gcloudf := func(argv ...string) ([]string, error) {
 		args := []string{"compute"}
 		args = append(args, argv...)
-		args = append(args, "--project", TestContext.CloudConfig.ProjectID,
-			"--zone", TestContext.CloudConfig.Zone)
+		args = append(args, "--project", TestContext.CloudConfig.ProjectID)
+		if TestContext.CloudConfig.MultiMaster {
+			args = append(args, "--region", TestContext.CloudConfig.Region)
+		} else {
+			args = append(args, "--zone", TestContext.CloudConfig.Zone)
+		}
 		outputBytes, err := exec.Command("gcloud", args...).CombinedOutput()
 		str := strings.Replace(string(outputBytes), ",", "\n", -1)
 		str = strings.Replace(str, ";", "\n", -1)
diff --git a/test/e2e/framework/nodes_util.go b/test/e2e/framework/nodes_util.go
index 7185da71ef6..651b5bc244e 100644
--- a/test/e2e/framework/nodes_util.go
+++ b/test/e2e/framework/nodes_util.go
@@ -120,10 +120,11 @@ func masterUpgradeGCE(rawV string, enableKubeProxyDaemonSet bool) error {
 }
 
 func locationParamGKE() string {
-	if TestContext.CloudConfig.Zone != "" {
-		return fmt.Sprintf("--zone=%s", TestContext.CloudConfig.Zone)
+	if TestContext.CloudConfig.MultiMaster {
+		// GKE Regional Clusters are being tested.
+		return fmt.Sprintf("--region=%s", TestContext.CloudConfig.Region)
 	}
-	return fmt.Sprintf("--region=%s", TestContext.CloudConfig.Region)
+	return fmt.Sprintf("--zone=%s", TestContext.CloudConfig.Zone)
 }
 
 func appendContainerCommandGroupIfNeeded(args []string) []string {
diff --git a/test/e2e/framework/test_context.go b/test/e2e/framework/test_context.go
index 6092eaa9fb7..e5e1fc93ca4 100644
--- a/test/e2e/framework/test_context.go
+++ b/test/e2e/framework/test_context.go
@@ -161,6 +161,7 @@ type CloudConfig struct {
 	Zone              string // for multizone tests, arbitrarily chosen zone
 	Region            string
 	MultiZone         bool
+	MultiMaster       bool
 	Cluster           string
 	MasterName        string
 	NodeInstanceGroup string // comma-delimited list of groups' names
@@ -245,6 +246,7 @@ func RegisterClusterFlags() {
 	flag.StringVar(&cloudConfig.Zone, "gce-zone", "", "GCE zone being used, if applicable")
 	flag.StringVar(&cloudConfig.Region, "gce-region", "", "GCE region being used, if applicable")
 	flag.BoolVar(&cloudConfig.MultiZone, "gce-multizone", false, "If true, start GCE cloud provider with multizone support.")
+	flag.BoolVar(&cloudConfig.MultiMaster, "gce-multimaster", false, "If true, the underlying GCE/GKE cluster is assumed to be multi-master.")
 	flag.StringVar(&cloudConfig.Cluster, "gke-cluster", "", "GKE name of cluster being used, if applicable")
 	flag.StringVar(&cloudConfig.NodeInstanceGroup, "node-instance-group", "", "Name of the managed instance group for nodes. Valid only for gce, gke or aws. If there is more than one group: comma separated list of groups.")
 	flag.StringVar(&cloudConfig.Network, "network", "e2e", "The cloud provider network for this e2e cluster.")