diff --git a/cmd/kube-controller-manager/app/options/options.go b/cmd/kube-controller-manager/app/options/options.go
index 5b834261fa7..e5acccd066b 100644
--- a/cmd/kube-controller-manager/app/options/options.go
+++ b/cmd/kube-controller-manager/app/options/options.go
@@ -69,9 +69,6 @@ func NewCMServer() *CMServer {
 			ConcurrentDeploymentSyncs:                       5,
 			ConcurrentNamespaceSyncs:                        10,
 			ConcurrentSATokenSyncs:                          5,
-			LookupCacheSizeForRC:                            4096,
-			LookupCacheSizeForRS:                            4096,
-			LookupCacheSizeForDaemonSet:                     1024,
 			ServiceSyncPeriod:                               metav1.Duration{Duration: 5 * time.Minute},
 			RouteReconciliationPeriod:                       metav1.Duration{Duration: 10 * time.Second},
 			ResourceQuotaSyncPeriod:                         metav1.Duration{Duration: 5 * time.Minute},
@@ -144,15 +141,6 @@ func (s *CMServer) AddFlags(fs *pflag.FlagSet, allControllers []string, disabled
 	fs.Int32Var(&s.ConcurrentDeploymentSyncs, "concurrent-deployment-syncs", s.ConcurrentDeploymentSyncs, "The number of deployment objects that are allowed to sync concurrently. Larger number = more responsive deployments, but more CPU (and network) load")
 	fs.Int32Var(&s.ConcurrentNamespaceSyncs, "concurrent-namespace-syncs", s.ConcurrentNamespaceSyncs, "The number of namespace objects that are allowed to sync concurrently. Larger number = more responsive namespace termination, but more CPU (and network) load")
 	fs.Int32Var(&s.ConcurrentSATokenSyncs, "concurrent-serviceaccount-token-syncs", s.ConcurrentSATokenSyncs, "The number of service account token objects that are allowed to sync concurrently. Larger number = more responsive token generation, but more CPU (and network) load")
-	// TODO(#43388): Remove the following flag 6 months after v1.6.0 is released.
-	fs.Int32Var(&s.LookupCacheSizeForRC, "replication-controller-lookup-cache-size", s.LookupCacheSizeForRC, "This flag is deprecated and will be removed in future releases. ReplicationController no longer requires a lookup cache.")
-	fs.MarkDeprecated("replication-controller-lookup-cache-size", "This flag is deprecated and will be removed in future releases. ReplicationController no longer requires a lookup cache.")
-	// TODO(#43388): Remove the following flag 6 months after v1.6.0 is released.
-	fs.Int32Var(&s.LookupCacheSizeForRS, "replicaset-lookup-cache-size", s.LookupCacheSizeForRS, "This flag is deprecated and will be removed in future releases. ReplicaSet no longer requires a lookup cache.")
-	fs.MarkDeprecated("replicaset-lookup-cache-size", "This flag is deprecated and will be removed in future releases. ReplicaSet no longer requires a lookup cache.")
-	// TODO(#43388): Remove the following flag 6 months after v1.6.0 is released.
-	fs.Int32Var(&s.LookupCacheSizeForDaemonSet, "daemonset-lookup-cache-size", s.LookupCacheSizeForDaemonSet, "This flag is deprecated and will be removed in future releases. DaemonSet no longer requires a lookup cache.")
-	fs.MarkDeprecated("daemonset-lookup-cache-size", "This flag is deprecated and will be removed in future releases. DaemonSet no longer requires a lookup cache.")
 	fs.DurationVar(&s.ServiceSyncPeriod.Duration, "service-sync-period", s.ServiceSyncPeriod.Duration, "The period for syncing services with their external load balancers")
 	fs.DurationVar(&s.NodeSyncPeriod.Duration, "node-sync-period", 0, ""+
 		"This flag is deprecated and will be removed in future releases. See node-monitor-period for Node health checking or "+
diff --git a/pkg/apis/componentconfig/types.go b/pkg/apis/componentconfig/types.go
index bd99e466313..1cf5cb20c6e 100644
--- a/pkg/apis/componentconfig/types.go
+++ b/pkg/apis/componentconfig/types.go
@@ -299,19 +299,6 @@ type KubeControllerManagerConfiguration struct {
 	ConcurrentSATokenSyncs int32
 	// lookupCacheSizeForRC is the size of lookup cache for replication controllers.
 	// Larger number = more responsive replica management, but more MEM load.
-	// TODO(#43388): Remove the following flag 6 months after v1.6.0 is released.
-	// DEPRECATED: This is no longer used.
-	LookupCacheSizeForRC int32
-	// lookupCacheSizeForRS is the size of lookup cache for replicatsets.
-	// Larger number = more responsive replica management, but more MEM load.
-	// TODO(#43388): Remove the following flag 6 months after v1.6.0 is released.
-	// DEPRECATED: This is no longer used.
-	LookupCacheSizeForRS int32
-	// lookupCacheSizeForDaemonSet is the size of lookup cache for daemonsets.
-	// Larger number = more responsive daemonset, but more MEM load.
-	// TODO(#43388): Remove the following flag 6 months after v1.6.0 is released.
-	// DEPRECATED: This is no longer used.
-	LookupCacheSizeForDaemonSet int32
 	// serviceSyncPeriod is the period for syncing services with their external
 	// load balancers.
 	ServiceSyncPeriod metav1.Duration