diff --git a/test/e2e_node/resource_metrics_test.go b/test/e2e_node/resource_metrics_test.go
index 28f1fed97fd..54a9c93c055 100644
--- a/test/e2e_node/resource_metrics_test.go
+++ b/test/e2e_node/resource_metrics_test.go
@@ -22,10 +22,12 @@ import (
 	"time"
 
 	metav1 "k8s.io/apimachinery/pkg/apis/meta/v1"
+	"k8s.io/kubernetes/pkg/features"
 	"k8s.io/kubernetes/test/e2e/framework"
 	e2ekubectl "k8s.io/kubernetes/test/e2e/framework/kubectl"
 	e2emetrics "k8s.io/kubernetes/test/e2e/framework/metrics"
 	e2epod "k8s.io/kubernetes/test/e2e/framework/pod"
+	e2eskipper "k8s.io/kubernetes/test/e2e/framework/skipper"
 	e2evolume "k8s.io/kubernetes/test/e2e/framework/volume"
 	"k8s.io/kubernetes/test/e2e/nodefeature"
 	admissionapi "k8s.io/pod-security-admission/api"
@@ -74,6 +76,17 @@ var _ = SIGDescribe("ResourceMetricsAPI", nodefeature.ResourceMetrics, func() {
 			memoryCapacity := node.Status.Capacity["memory"]
 			memoryLimit := memoryCapacity.Value()
 
+			keys := []string{
+				"resource_scrape_error", "node_cpu_usage_seconds_total", "node_memory_working_set_bytes",
+				"pod_cpu_usage_seconds_total", "pod_memory_working_set_bytes",
+			}
+
+			// NOTE: This check should be removed when ListMetricDescriptors is implemented
+			// by CRI-O and Containerd
+			if !e2eskipper.IsFeatureGateEnabled(features.PodAndContainerStatsFromCRI) {
+				keys = append(keys, "container_cpu_usage_seconds_total", "container_memory_working_set_bytes", "container_start_time_seconds")
+			}
+
 			matchResourceMetrics := gomega.And(gstruct.MatchKeys(gstruct.IgnoreMissing, gstruct.Keys{
 				"resource_scrape_error": gstruct.Ignore(),
 				"node_cpu_usage_seconds_total": gstruct.MatchAllElements(nodeID, gstruct.Elements{
@@ -113,8 +126,7 @@ var _ = SIGDescribe("ResourceMetricsAPI", nodefeature.ResourceMetrics, func() {
 					fmt.Sprintf("%s::%s", f.Namespace.Name, pod1): boundedSample(0*e2evolume.Kb, 80*e2evolume.Mb),
 				}),
 			}),
-				haveKeys("resource_scrape_error", "node_cpu_usage_seconds_total", "node_memory_working_set_bytes", "container_cpu_usage_seconds_total",
-					"container_memory_working_set_bytes", "container_start_time_seconds", "pod_cpu_usage_seconds_total", "pod_memory_working_set_bytes"),
+				haveKeys(keys...),
 			)
 			ginkgo.By("Giving pods a minute to start up and produce metrics")
 			gomega.Eventually(ctx, getResourceMetrics, 1*time.Minute, 15*time.Second).Should(matchResourceMetrics)