diff --git a/test/e2e_node/hugepages_test.go b/test/e2e_node/hugepages_test.go
index cfd3d4188cb..773bbc3d308 100644
--- a/test/e2e_node/hugepages_test.go
+++ b/test/e2e_node/hugepages_test.go
@@ -118,7 +118,7 @@ func makePodToVerifyHugePages(baseName string, hugePagesLimit resource.Quantity,
 }
 
 // configureHugePages attempts to allocate hugepages of the specified size
-func configureHugePages(hugepagesSize int, hugepagesCount int) error {
+func configureHugePages(hugepagesSize int, hugepagesCount int, numaNodeID *int) error {
 	// Compact memory to make bigger contiguous blocks of memory available
 	// before allocating huge pages.
 	// https://www.kernel.org/doc/Documentation/sysctl/vm.txt
@@ -128,16 +128,26 @@ func configureHugePages(hugepagesSize int, hugepagesCount int) error {
 		}
 	}
 
+	// e.g. hugepages/hugepages-2048kB/nr_hugepages
+	hugepagesSuffix := fmt.Sprintf("hugepages/hugepages-%dkB/%s", hugepagesSize, hugepagesCapacityFile)
+
+	// e.g. /sys/kernel/mm/hugepages/hugepages-2048kB/nr_hugepages
+	hugepagesFile := fmt.Sprintf("/sys/kernel/mm/%s", hugepagesSuffix)
+	if numaNodeID != nil {
+		// e.g. /sys/devices/system/node/node0/hugepages/hugepages-2048kB/nr_hugepages
+		hugepagesFile = fmt.Sprintf("/sys/devices/system/node/node%d/%s", *numaNodeID, hugepagesSuffix)
+	}
+
 	// Reserve number of hugepages
-	// e.g. /bin/sh -c "echo 5 > /sys/kernel/mm/hugepages/hugepages-2048kB/vm.nr_hugepages"
-	command := fmt.Sprintf("echo %d > %s-%dkB/%s", hugepagesCount, hugepagesDirPrefix, hugepagesSize, hugepagesCapacityFile)
+	// e.g. /bin/sh -c "echo 5 > /sys/kernel/mm/hugepages/hugepages-2048kB/nr_hugepages"
+	command := fmt.Sprintf("echo %d > %s", hugepagesCount, hugepagesFile)
 	if err := exec.Command("/bin/sh", "-c", command).Run(); err != nil {
 		return err
 	}
 
 	// verify that the number of hugepages was updated
 	// e.g. /bin/sh -c "cat /sys/kernel/mm/hugepages/hugepages-2048kB/vm.nr_hugepages"
-	command = fmt.Sprintf("cat %s-%dkB/%s", hugepagesDirPrefix, hugepagesSize, hugepagesCapacityFile)
+	command = fmt.Sprintf("cat %s", hugepagesFile)
 	outData, err := exec.Command("/bin/sh", "-c", command).Output()
 	if err != nil {
 		return err
@@ -258,7 +268,7 @@ var _ = SIGDescribe("HugePages [Serial] [Feature:HugePages][NodeSpecialFeature:H
 
 				ginkgo.By(fmt.Sprintf("Configuring the host to reserve %d of pre-allocated hugepages of size %d", count, size))
 				gomega.Eventually(func() error {
-					if err := configureHugePages(size, count); err != nil {
+					if err := configureHugePages(size, count, nil); err != nil {
 						return err
 					}
 					return nil
diff --git a/test/e2e_node/memory_manager_test.go b/test/e2e_node/memory_manager_test.go
index af3d948e025..bba3b5dc602 100644
--- a/test/e2e_node/memory_manager_test.go
+++ b/test/e2e_node/memory_manager_test.go
@@ -324,7 +324,7 @@ var _ = SIGDescribe("Memory Manager [Disruptive] [Serial] [Feature:MemoryManager
 		if *is2MiHugepagesSupported {
 			ginkgo.By("Configuring hugepages")
 			gomega.Eventually(func() error {
-				return configureHugePages(hugepagesSize2M, hugepages2MiCount)
+				return configureHugePages(hugepagesSize2M, hugepages2MiCount, pointer.IntPtr(0))
 			}, 30*time.Second, framework.Poll).Should(gomega.BeNil())
 		}
 	})
@@ -356,7 +356,8 @@ var _ = SIGDescribe("Memory Manager [Disruptive] [Serial] [Feature:MemoryManager
 		if *is2MiHugepagesSupported {
 			ginkgo.By("Releasing allocated hugepages")
 			gomega.Eventually(func() error {
-				return configureHugePages(hugepagesSize2M, 0)
+				// configure hugepages on the NUMA node 0 to avoid hugepages split across NUMA nodes
+				return configureHugePages(hugepagesSize2M, 0, pointer.IntPtr(0))
 			}, 90*time.Second, 15*time.Second).ShouldNot(gomega.HaveOccurred(), "failed to release hugepages")
 		}
 	})