diff --git a/test/e2e/framework/service/BUILD b/test/e2e/framework/service/BUILD
index 43be89af1c3..3af1bb6cf31 100644
--- a/test/e2e/framework/service/BUILD
+++ b/test/e2e/framework/service/BUILD
@@ -13,6 +13,7 @@ go_library(
     visibility = ["//visibility:public"],
     deps = [
         "//staging/src/k8s.io/api/core/v1:go_default_library",
+        "//staging/src/k8s.io/api/discovery/v1beta1:go_default_library",
         "//staging/src/k8s.io/api/policy/v1beta1:go_default_library",
         "//staging/src/k8s.io/apimachinery/pkg/api/errors:go_default_library",
         "//staging/src/k8s.io/apimachinery/pkg/apis/meta/v1:go_default_library",
diff --git a/test/e2e/framework/service/jig.go b/test/e2e/framework/service/jig.go
index b1c48b1376f..5eaf83b7523 100644
--- a/test/e2e/framework/service/jig.go
+++ b/test/e2e/framework/service/jig.go
@@ -28,6 +28,7 @@ import (
 
 	"github.com/onsi/ginkgo"
 	v1 "k8s.io/api/core/v1"
+	discoveryv1beta1 "k8s.io/api/discovery/v1beta1"
 	policyv1beta1 "k8s.io/api/policy/v1beta1"
 	apierrors "k8s.io/apimachinery/pkg/api/errors"
 	metav1 "k8s.io/apimachinery/pkg/apis/meta/v1"
@@ -352,6 +353,8 @@ func (j *TestJig) waitForAvailableEndpoint(timeout time.Duration) error {
 	endpointSelector := fields.OneTermEqualSelector("metadata.name", j.Name)
 	stopCh := make(chan struct{})
 	endpointAvailable := false
+	endpointSliceAvailable := false
+
 	var controller cache.Controller
 	_, controller = cache.NewInformer(
 		&cache.ListWatch{
@@ -390,8 +393,54 @@ func (j *TestJig) waitForAvailableEndpoint(timeout time.Duration) error {
 
 	go controller.Run(stopCh)
 
+	// If EndpointSlice API is enabled, then validate if appropriate EndpointSlice objects were also create/updated/deleted.
+	if _, err := j.Client.Discovery().ServerResourcesForGroupVersion(discoveryv1beta1.SchemeGroupVersion.String()); err == nil {
+		var esController cache.Controller
+		_, esController = cache.NewInformer(
+			&cache.ListWatch{
+				ListFunc: func(options metav1.ListOptions) (runtime.Object, error) {
+					options.LabelSelector = "kubernetes.io/service-name=" + j.Name
+					obj, err := j.Client.DiscoveryV1beta1().EndpointSlices(j.Namespace).List(context.TODO(), options)
+					return runtime.Object(obj), err
+				},
+				WatchFunc: func(options metav1.ListOptions) (watch.Interface, error) {
+					options.LabelSelector = "kubernetes.io/service-name=" + j.Name
+					return j.Client.DiscoveryV1beta1().EndpointSlices(j.Namespace).Watch(context.TODO(), options)
+				},
+			},
+			&discoveryv1beta1.EndpointSlice{},
+			0,
+			cache.ResourceEventHandlerFuncs{
+				AddFunc: func(obj interface{}) {
+					if es, ok := obj.(*discoveryv1beta1.EndpointSlice); ok {
+						// TODO: currently we only consider addreses in 1 slice, but services with
+						// a large number of endpoints (>1000) may have multiple slices. Some slices
+						// with only a few addresses. We should check the addresses in all slices.
+						if len(es.Endpoints) > 0 && len(es.Endpoints[0].Addresses) > 0 {
+							endpointSliceAvailable = true
+						}
+					}
+				},
+				UpdateFunc: func(old, cur interface{}) {
+					if es, ok := cur.(*discoveryv1beta1.EndpointSlice); ok {
+						// TODO: currently we only consider addreses in 1 slice, but services with
+						// a large number of endpoints (>1000) may have multiple slices. Some slices
+						// with only a few addresses. We should check the addresses in all slices.
+						if len(es.Endpoints) > 0 && len(es.Endpoints[0].Addresses) > 0 {
+							endpointSliceAvailable = true
+						}
+					}
+				},
+			},
+		)
+
+		go esController.Run(stopCh)
+
+	} else {
+		endpointSliceAvailable = true
+	}
 	err := wait.Poll(1*time.Second, timeout, func() (bool, error) {
-		return endpointAvailable, nil
+		return endpointAvailable && endpointSliceAvailable, nil
 	})
 	if err != nil {
 		return fmt.Errorf("no subset of available IP address found for the endpoint %s within timeout %v", j.Name, timeout)