diff --git a/Makefile b/Makefile
index af19a7b8..3f2ea602 100644
--- a/Makefile
+++ b/Makefile
@@ -5,6 +5,13 @@ export GO15VENDOREXPERIMENT=1
 ifeq ($(shell uname),Darwin)
 PREFIX ?= ${DESTDIR}/usr/local
 DARWIN_BUILD_TAG=containers_image_ostree_stub
+# On macOS, (brew install gpgme) installs it within /usr/local, but /usr/local/include is not in the default search path.
+# Rather than hard-code this directory, use gpgme-config. Sadly that must be done at the top-level user
+# instead of locally in the gpgme subpackage, because cgo supports only pkg-config, not general shell scripts,
+# and gpgme does not install a pkg-config file.
+# If gpgme is not installed or gpgme-config can’t be found for other reasons, the error is silently ignored
+# (and the user will probably find out because the cgo compilation will fail).
+GPGME_ENV := CGO_CFLAGS="$(shell gpgme-config --cflags 2>/dev/null)" CGO_LDFLAGS="$(shell gpgme-config --libs 2>/dev/null)"
 else
 PREFIX ?= ${DESTDIR}/usr
 endif
@@ -64,10 +71,10 @@ binary-static: cmd/skopeo
 
 # Build w/o using Docker containers
 binary-local:
-	$(GO) build -ldflags "-X main.gitCommit=${GIT_COMMIT}" -gcflags "$(GOGCFLAGS)" -tags "$(BUILDTAGS)" -o skopeo ./cmd/skopeo
+	$(GPGME_ENV) $(GO) build -ldflags "-X main.gitCommit=${GIT_COMMIT}" -gcflags "$(GOGCFLAGS)" -tags "$(BUILDTAGS)" -o skopeo ./cmd/skopeo
 
 binary-local-static:
-	$(GO) build -ldflags "-extldflags \"-static\" -X main.gitCommit=${GIT_COMMIT}" -gcflags "$(GOGCFLAGS)" -tags "$(BUILDTAGS)" -o skopeo ./cmd/skopeo
+	$(GPGME_ENV) $(GO) build -ldflags "-extldflags \"-static\" -X main.gitCommit=${GIT_COMMIT}" -gcflags "$(GOGCFLAGS)" -tags "$(BUILDTAGS)" -o skopeo ./cmd/skopeo
 
 build-container:
 	docker build ${DOCKER_BUILD_ARGS} -t "$(DOCKER_IMAGE)" .
@@ -123,4 +130,4 @@ validate-local:
 	hack/make.sh validate-git-marks validate-gofmt validate-lint validate-vet
 
 test-unit-local:
-	$(GO) test -tags "$(BUILDTAGS)" $$($(GO) list -tags "$(BUILDTAGS)" -e ./... | grep -v '^github\.com/projectatomic/skopeo/\(integration\|vendor/.*\)$$')
+	$(GPGME_ENV) $(GO) test -tags "$(BUILDTAGS)" $$($(GO) list -tags "$(BUILDTAGS)" -e ./... | grep -v '^github\.com/projectatomic/skopeo/\(integration\|vendor/.*\)$$')